| Date | Time | Home | Score | Away | Venue |
|
| August 2010 |
| Fri 13 Aug | 19:30 | Currie | 34 - 13 | London Scottish | Malleny Park | Report |
| Sat 14 Aug | 15:00 | Ayr | 22 - 28 | London Scottish | MiIlbrae | Report |
| Sat 21 Aug | 15:00 | London Scottish | 12 - 67 | London Welsh | The Athletic Ground, Richmond | Report |
| Sat 28 Aug | 14:30 | Loughborough | 7 - 27 | London Scottish | Sports Development Centre | Report |
| September 2010 |
| Sat 4 Sep | 15:00 | London Scottish | v | Blackheath | The Athletic Ground, Richmond |
|
| Sat 11 Sep | 15:00 | London Scottish | v | Barking | The Athletic Ground, Richmond |
|
| Sat 18 Sep | 14:30 | Rosslyn Park | v | London Scottish | Priory Lane |
|
| Sat 25 Sep | 15:00 | London Scottish | v | Redruth | The Athletic Ground, Richmond |
|
| October 2010 |
| Sat 2 Oct | 15:00 | Otley | v | London Scottish | Cross Green |
|
| Sat 9 Oct | 14:30 | London Scottish | v | Tynedale | The Athletic Ground, Richmond |
|
| Sat 16 Oct | 15:00 | Stourbridge | v | London Scottish | Stourton Park |
|
| Sat 23 Oct | 15:00 | London Scottish | v | Sedgley Park | The Athletic Ground, Richmond |
|
| Sat 30 Oct | 15:00 | Cinderford | v | London Scottish | The Recreation Ground |
|
| November 2010 |
| Sat 6 Nov | 15:00 | London Scottish | v | Cambridge | The Athletic Ground, Richmond |
|
| Sat 13 Nov | 15:00 | Macclesfield | v | London Scottish | Priory Park |
|
| Sat 20 Nov | 15:00 | London Scottish | v | Coventry | The Athletic Ground, Richmond |
|
| Sat 27 Nov | 14:15 | Blaydon | v | London Scottish | Crow Trees Green |
|
| December 2010 |
| Sat 4 Dec | 15:00 | London Scottish | v | Wharfedale | The Athletic Ground, Richmond |
|
| Sat 11 Dec | 14:30 | Launceston | v | London Scottish | Polson Bridge |
|
| Sat 18 Dec | 15:00 | Barking | v | London Scottish | Goresbrook |
|
| January 2011 |
| Sat 8 Jan | 15:00 | London Scottish | v | Rosslyn Park | The Athletic Ground, Richmond |
|
| Sat 15 Jan | 14:00 | Redruth | v | London Scottish | Cross Green |
|
| Sat 22 Jan | 15:00 | London Scottish | v | Otley | The Athletic Ground, Richmond |
|
| Sat 29 Jan | 15:00 | Tynedale | v | London Scottish | Tynedale Park |
|
| February 2011 |
| Sat 12 Feb | 15:00 | London Scottish | v | Stourbridge | The Athletic Ground, Richmond |
|
| Sat 19 Feb | 15:00 | Sedgley Park | v | London Scottish | Park Lane |
|
| March 2011 |
| Sat 5 Mar | 15:00 | London Scottish | v | Cinderford | The Athletic Ground, Richmond |
|
| Sat 12 Mar | 15:00 | Cambridge | v | London Scottish | West Renaults Park |
|
| Sat 26 Mar | 15:00 | London Scottish | v | Macclesfield | The Athletic Ground, Richmond |
|
| April 2011 |
| Sat 2 Apr | 14:00 | Coventry | v | London Scottish | Butts Park Arena |
|
| Sat 9 Apr | 14:00 | London Scottish | v | Blaydon | The Athletic Ground, Richmond |
|
| Sat 16 Apr | 15:00 | Wharfedale | v | London Scottish | Wharfeside Avenue |
|
| Sat 23 Apr | 15:00 | London Scottish | v | Launceston | The Athletic Ground, Richmond |
|
| Sat 30 Apr | 15:00 | Blackheath | v | London Scottish | The Rectory Field |
|